CDFI鉴别男性乳腺良恶性肿瘤价值及与CXCL1、Gab2、MVD的相关性探究

本研究选取18例男性乳腺恶性肿瘤患者作为研究组,纳入同期41例男性良性乳腺肿瘤及50例健康体检男性分别作为良性对照组和健康对照组,通过对比分析发现,研究组CDFI参数搏动指数(PI)、阻力指数(RI)、血流速度(PSV)]高于良性对照组和健康对照组(P<0.05);PI、RI、PSV联合诊断男性乳腺恶性肿瘤的AUC高达0.854,具有较高应用价值;研究组患者PI、RI、PSV与CXC型趋化因子配体1(CXCL1)、GRB相关蛋白2(Gab2)、微血管密度(MVD)水平间存在正相关关系(P<0.05)。由此可见,CDFI在鉴别男性乳腺良恶性肿瘤方面具有较高应用价值,且与患者CXCL1、Gab2、MVD表达呈正相关。

The Value of CDFI in Identifying Benign and Malignant Tumors of Male Breast and Its Correlation with CXCL1, Gab2 and MVD

In this article,18 male patients with malignant breast tumors were selected as the research group,while 41 male with benign breast tumors and 50 healthy males in the same period were included as benign control group and healthy control group.Through comparative analysis,it was found that the CDFI parameterspulse index(PI),resistance index(RI),blood flow velocity(PSV)]of the research group were higher than those of the benign control group and the healthy control group(P<0.05).The combined AUC value of PI,RI and PSV in the diagnosis of male breast malignant tumors was as high as 0.854,which was of a high application value.In the research group,there was a positive correlation between PI,RI,PSV and the level of CXC type chemokine ligand 1(CXCL1),as well as the level of GRB related protein 2(Gab2)and microvessel density(MVD)(P<0.05).Our research showed that CDFI had a high application value in identifying benign and malignant breast tumors in men,and it is positively correlated with the expression of CXCL1,Gab2 and MVD in patients.