Syntheses and thermal properties of some complexes with 2-mercaptonicotinic acid |
| |
| Authors: | Q. Yang S. Chen S. Gao |
| |
| Affiliation: | (1) School of Sciences, Wuhan University of Technology, Wuhan, 430070, China;(2) College of Chemistry and Molecular Science, Wuhan University, Wuhan, 430072, China;(3) State key laboratory of agricultural microbiology, Huazhong Agricultural University, Wuhan, 430070, China;(4) School of Material Science and Technology, Wuhan University of Technology, Wuhan, 430070, China |
| |
| Abstract: | The biological activity of a kind of hetero-bimetallic Schiff-base complex was studied using Escherichia coli (E. coli) cell as the target. By microcalorimetry, the difference of anti-bacterial activity between the binuclear Schiff-base and the ligand was determined and analyzed. To analyze the inhibition of the bacterial growth internally, the E. coli cells grown in the presence of hetero-bimetallic Schiff-base complex were observed by scanning electron microscopy. The images in high resolution revealed the damage of outer cell membrane caused the inhibitory effect on E. coli. Inductively coupled plasma-mass spectrometry results proved the absorption of the complex by cells, which confirmed the interaction between the Schiff-base and biological macromolecule. |
| |
| Keywords: | anti-bacterial coordination inhibition microcalorimetry Schiff-base |
| 本文献已被 SpringerLink 等数据库收录！ |
|
