Total synthesis of (-)-dictyostatin |
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| Authors: | O'Neil Gregory W Phillips Andrew J |
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| Affiliation: | Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA. |
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| Abstract: | ![]()
A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated cyclizations of (silyloxy)enynes for the synthesis of stereotriads, a subunit coupling by metathesis, and macrocyclization by intramolecular Horner-Wadsworth-Emmons olefination. |
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