Synthesis of substituted pyrazoles via tandem cross-coupling/electrocyclization of enol triflates and diazoacetates |
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| Authors: | Babinski David J Aguilar Hector R Still Raymond Frantz Doug E |
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| Institution: | Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, USA. |
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| Abstract: | The synthesis of 3,4,5-trisubstituted pyrazoles via a tandem catalytic cross-coupling/electrocyclization of enol triflates and diazoacetates is presented. The initial scope of this methodology is demonstrated on a range of differentially substituted acyclic and cyclic enol triflates as well as an elaborated set of diazoacetates to provide the corresponding pyrazoles with a high degree of structural complexity. |
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