ULTRAVIOLET-ENHANCED REACTIVATION OF HERPES VIRUS IN HUMAN TUMOR CELLS |
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| Authors: | C. D. Lytle S. G. Benane L. E. Bockstahler |
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| Affiliation: | Division of Biological Effects, Bureau of Radiological Health, Food and Drug Administration. U.S. Public Health Service, Department of Health, Education, and Welfare, Rockville, Maryland 20852 U.S.A. |
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| Abstract: | ![]()
Abstract —Virus-host cell interactions may be investigated by study of the enhancement of infectivity of ultraviolet (UV)-irradiated virus obtained by UV-irradiating the host cell [ultraviolet reactivation (UVR)]. This phenomenon was studied with Herpes simplex virus and normal (embryonic lung) and malignant (HeLa) human cells. Although the lung cells displayed no UVR, both the HeLa cells and a Sendai-virus carrier culture of HeLa cells demonstrated UVR capabilities. This UVR persisted at equal or increased levels for at least 24 h. Since the lung cells and HeLa cells have similar host-cell-reactivation (HCR) abilities, the differences in UVR suggests that UVR and HCR may operate by different mechanisms. |
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