Voltammetric Determination of Metronidazole Using a Sensor Based on Electropolymerization of α‐Cyclodextrin over a Carbon Paste Electrode |
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| Authors: | Arturo Hernández‐Jiménez Gabriela Roa‐Morales Horacio Reyes‐Pérez Patricia Balderas‐Hernández Carlos E Barrera‐Díaz Margarita Bernabé‐Pineda |
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| Institution: | 1. Centro Conjunto de Investigación en Química Sustentable UAEM‐UNAM, Km 14.5 Carretera Toluca‐Atlacomulco, Campus UAEMex ‘‘El Rosedal' San Cayetano‐Toluca, C.P. 50200 Toluca, México;2. Facultad de Química, Universidad Autónoma del Estado de México, Avenida Paseo Tollocan S/N, C.P 50120 Toluca, México;3. Universidad de la Ca?ada, Instituto de Farmacobiología, Carretera Teotitlán – San Antonio Nanahuatipán km 1.7 s/n. Paraje Titlacuatitla. Teotitlán de Flores Magón, C.P. 68540, Oaxaca, México |
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| Abstract: | An electrochemical sensor for metronidazole (MTZ) was built via the surface modification of a carbon paste electrode (CPE) by a film obtained through electropolymerization of α‐cyclodextrin (CPEα‐CD). The CPEα‐CD was characterized by cyclic voltammetry (CV) and atomic force microscopy (AFM), by both techniques was demonstrated that the polymer film is coating the electrode surface. The electroreduction behaviour of MTZ in HClO4 media as a supporting electrolyte was studied by differential‐pulse voltammetric (DPV) technique. The DPV electrochemical process was observed to be diffusion controlled and irreversible. Under optimal conditions, the peak current was proportional to MTZ concentration in the range of 0.5 to 103.0 μM with a detection limit of 0.28±0.02 μM. The method was successfully applied to quantify of MTZ in pharmaceutical formulations. In addition, this proposed MTZ sensor exhibited good reproducibility, long‐term stability and fast current response. |
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| Keywords: | α ‐cyclodextrin Metronidazole Carbon paste electrode Differential Pulse Voltammetry Cyclic Voltammetry |
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