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Domino Staudinger/aza‐Wittig/Mannich Reaction: An Approach to Diversity of Di‐ and Tetrahydropyrrole Scaffolds |
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| Authors: | Dr. Anna S. Pavlova Dr. Olga A. Ivanova Dr. Alexey O. Chagarovskiy Nikolay S. Stebunov Dr. Nikolay V. Orlov Dr. Alexey N. Shumsky Dr. Ekaterina M. Budynina Dr. Victor B. Rybakov Prof. Dr. Igor V. Trushkov |
| Affiliation: | 1. Department of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russian Federation;2. Laboratory of Chemical Synthesis, Federal Research Center of Pediatric Hematology, Oncology and Immunology n.a. Dmitriy Rogachev, Moscow, Russian Federation;3. Faculty of Science, Russian University of People's Friendship, Moscow, Russian Federation;4. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation;5. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russian Federation |
| Abstract: | A highly efficient and selective domino reaction producing valuable di‐ and tetrahydropyrrole‐based skeletons from azidoethyl‐substituted CH‐acids and (thio)carbonyl compounds has been developed. By involving the additional functional groups in starting compounds into the domino reaction or postmodification of the primary reaction products, the simple construction of the pharmaceutically relevant three‐ and polycyclic azaheterocyclic scaffolds was demonstrated. |
| Keywords: | azides domino reactions donor– acceptor cyclopropanes nitrogen heterocycles synthesis design |