Nickel‐Catalyzed N‐Arylation of Primary Amides and Lactams with Activated (Hetero)aryl Electrophiles |
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Authors: | Christopher M Lavoie Preston M MacQueen Prof Dr Mark Stradiotto |
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Institution: | Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada |
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Abstract: | The first nickel‐catalyzed N‐arylation of amides with (hetero)aryl (pseudo)halides is reported, enabled by use of the air‐stable pre‐catalyst (PAd‐DalPhos)Ni(o‐tolyl)Cl ( C1 ). A range of structurally diverse primary amides and lactams were cross‐coupled successfully with activated (hetero)aryl chloride, bromide, triflate, tosylate, mesylate, and sulfamate electrophiles. |
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Keywords: | amide cross-coupling lactam ligand design nickel |
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