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Boswellic Acids Show In Vitro Activity against Leishmania donovani |
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| Authors: | Hippolyt L Greve Marcel Kaiser Pascal Mser Thomas J Schmidt |
| Institution: | 1.Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, Pharma Campus–Corrensstrasse 48, D-48149 Münster, Germany;2.Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4051 Basel, Switzerland; (M.K.); (P.M.);3.University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland |
| Abstract: | In continuation of our search for leads from medicinal plants against protozoal pathogens, we detected antileishmanial activity in polar fractions of a dichloromethane extract from Boswellia serrata resin. 11-keto-β-boswellic acid (KBA) could be isolated from these fractions and was tested in vitro against Leishmania donovani axenic amastigotes along with five further boswellic acid derivatives. 3-O-acetyl-11-keto-β-boswellic acid (AKBA) showed the strongest activity with an IC50 value of 0.88 µM against axenic amastigotes but was inactive against intracellular amastigotes in murine macrophages |
| Keywords: | Boswellia serrata frankincense Burseraceae Leishmania donovani antiprotozoal activity boswellic acids |