The protection of 2′-hydroxy functions in oligoribonucleotide synthesis |
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| Authors: | David G. Norman Colin B. Reese Halina T. Serafinowska |
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| Affiliation: | Department of Chemistry, King''s College, Strand, London WC2R 2LS, England |
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| Abstract: | The suitability of the 4-methoxytetrahydropyran-4-yl group for the protection of 2′ (or 3′)-hydroxy functions in oligoribonucleotide synthesis is confirmed; the latter protecting group is removed in 0.01M - hydrochloric acid at room temperature under conditions which, contrary to a recent report, lead to no detectable cleavage or migration of the internucleotide phosphodiester linkages. |
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