A new reagent for the mediation of amide bond formation in peptide synthesis. |
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| Authors: | Robert Ramage Christopher P. Ashton David Hopton Maxwell J. Parrott |
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| Affiliation: | Department of Chemistry, University of Manchester Institute of Science and Technology, Manchester M60 1QD, England. |
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| Abstract: | The potential application of 1-oxo-1-chlorophospholane (5) as a novel reagent for the in situ activation of Nα -protected amino acids for use in peptide bond forming reactions has been examined. Wherever possible, 32.4Mhz 31P nuclear magnetic resonance (n.m.r.) spectroscopy was employed to follow both the formation of the intermediate phospholanic-carboxylic mixed anhydride and the subsequent aminolysis reaction. |
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