Total synthesis of methyl protodioscin: a potent agent with antitumor activity |
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| Authors: | Cheng Mao S Wang Qian L Tian Quan Song Hong Y Liu Yong X Li Qiang Xu Xin Miao Hong D Yao Xin S Yang Zhen |
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| Affiliation: | School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, P. R. China. zyang@chem.pku.edu.cn |
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| Abstract: | Methyl protodioscin (1), otherwise known as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-d-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-22-methoxy-25(R)-furost-5-ene-3 beta,26-diol, has been synthesized for the first time from diosgenin through nine steps in an overall yield of 7.8%. |
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