Recent advances in application of liquid-based micro-extraction: A review

Liquid-based micro-extraction is a novel “green” sample preparation technique using micro-litre levels of organic solvent to extract target analytes from various sample matrices for subsequent instrumental analysis. This technique developed rapidly from its introduction in the mid-1990s. Micro-extraction methods can be conveniently combined with a wide selection of instruments commonly used in a chemical laboratory; they significantly reduce analysis time and costs of solvents’ use and waste disposal. This review focuses on recent advances in several liquid-based micro-extraction methods, including single-drop micro-extraction, hollow fibre-liquid phase micro-extraction, and dispersive liquid-liquid micro-extraction. Examples of application of these methods to environmental, food, and biomedical analysis are listed.