Asymmetric halo aldol reaction (AHA) |
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| Authors: | Li Guigen Xu Xin Chen Dianjun Timmons Cody Carducci Michael D Headley Allan D |
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| Institution: | Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA. qeggl@ttu.edu |
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| Abstract: | reaction: see text] The asymmetric halo aldol reaction (AHA) using Evans oxazolidinones as chiral auxiliaries has been established for tandem I-C/C-C bond formations. The new asymmetric reaction provides a practical approach to a variety of halo aldols of a non-Evans type that cannot be easily synthesized by other methods. Excellent diastereoselectivity (>95%) and yields (80-93%) have been obtained for eight examples. |
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