A new tool to assess ceramide bioactivity: 6-bromo-7-hydroxycoumarinyl-caged ceramide |
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| Authors: | Kim Young Ah Ramirez Daniel M Carter Costain Willard J Johnston Linda J Bittman Robert |
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| Affiliation: | Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, NY 11367, USA. |
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| Abstract: | ![]()
The bioactivity of natural, long-chain ceramides has until now been studied after its delivery to cells in organic solvent mixtures containing dodecane. We have synthesized ceramides conjugated to a (6-bromo-7-hydroxycoumarin-4-yl)methyl group. The photocaged ceramide is efficiently released with 350 nm light in aqueous solution at neutral pH, thus providing a promising new tool to study ceramide's properties. |
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