Synthesis and pharmacological activity of some synthesized polyazacyclopenta[a]naphthalenes and pyrazolo[3,4-b]pyridines using 2-amino-6-methyl-4-phenylnicotinonitrile as synthon |
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Authors: | Said Aly Said |
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Institution: | (1) Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt |
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Abstract: | Abstract A series of pyridines, pyrimidines, and their derivatives were synthesized using 2-amino-6-methyl-4-phenylnicotinonitrile
as starting material. Thirteen new heterocyclics containing a pyridine ring were thus prepared. Pharmacological screening
showed that many of these compounds have good anti-inflammatory and analgesic activity comparable with those of diclofenac
potassium and valdecoxib as reference drugs. Assignment of the structures of the new compounds was based on chemical and spectroscopic
evidence. Synthesis, spectroscopic data, and pharmacological properties of the compounds are reported in detail. |
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Keywords: | |
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