Mesoporous γ‐Iron Oxide Nanoparticles for Magnetically Triggered Release of Doxorubicin and Hyperthermia Treatment |
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Authors: | Dr Farah Benyettou Jaen Alonso Ocadiz?Flores Dr Florent Ravaux Dr Rachid Rezgui Dr Mustapha Jouiad Samer I Nehme Rajesh Kumar Parsapur Prof John‐Carl Olsen Prof Parasuraman Selvam Prof Ali Trabolsi |
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Institution: | 1. New York University, Abu Dhabi, United Arab Emirates;2. Department of Mechanical and Materials Engineering, Masdar Institute of Science and Technology, Abu Dhabi, United Arab Emirates;3. National Centre for Catalysis Research and Department of Chemistry, Indian Institute of Technology-Madras, Chennai, India;4. Department of Chemistry, University of Rochester, RC Box 270216, Rochester, NY, USA |
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Abstract: | Mesoporous iron‐oxide nanoparticles (mNPs) were prepared by using a modified nanocasting approach with mesoporous carbon as a hard template. mNPs were first loaded with doxorubicin (Dox), an anticancer drug, and then coated with the thermosensitive polymer Pluronic F108 to prevent the leakage of Dox molecules from the pores that would otherwise occur under physiological conditions. The Dox‐loaded, Pluronic F108‐coated system (Dox@F108‐mNPs) was stable at room temperature and physiological pH and released its Dox cargo slowly under acidic conditions or in a sudden burst with magnetic heating. No significant toxicity was observed in vitro when Dox@F108‐mNPs were incubated with noncancerous cells, a result consistent with the minimal internalization of the particles that occurs with normal cells. On the other hand, the drug‐loaded particles significantly reduced the viability of cervical cancer cells (HeLa, IC50=0.70 μm ), wild‐type ovarian cancer cells (A2780, IC50=0.50 μm ) and Dox‐resistant ovarian cancer cells (A2780/AD, IC50=0.53 μm ). In addition, the treatment of HeLa cells with both Dox@F108‐mNPs and subsequent alternating magnetic‐field‐induced hyperthermia was significantly more effective at reducing cell viability than either Dox or Dox@F108‐mNP treatment alone. Thus, Dox@F108‐mNPs constitute a novel soft/hard hybrid nanocarrier system that is highly stable under physiological conditions, temperature‐responsive, and has chemo‐ and thermotherapeutic modes of action. |
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Keywords: | controlled release doxorubicin mesoporous iron oxide nanotechnology thermo-chemotherapy |
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