Near‐Infrared‐Emitting BODIPY‐trisDOTA111In as a Monomolecular Multifunctional Imaging Probe: From Synthesis to In Vivo Investigations |
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| Authors: | Dr Claire Bernhard Dr Damien Lhenry Dr Mathieu Moreau Dr Sabin Carme Dr Alexandra Oudot Dr Bertrand Collin Dr Jean‐Marc Vrigneaud Dr Peggy Provent Prof François Brunotte Prof Franck Denat Dr Christine Goze |
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| Institution: | 1. ICMUB UMR CNRS 6302, CNRS, Univ. Bourgogne Franche-Comté, Dijon, France;2. Centre Georges Fran?ois Leclerc, Service de médecine nucléaire, Dijon Cedex, France;3. Oncodesign, Dijon CEDEX, France;4. (+33)?380396117 |
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| Abstract: | A new generation of monomolecular imaging probes (MOMIP) based on a distyryl‐BODIPY (BODIPY=boron‐dipyrromethene) coupled with three DOTA macrocycles has been prepared (DOTA=1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid). The MOMIP presents good fluorescence properties and is very stable in serum. The bimodal probe was conjugated to trastuzumab, and an optical in vivo study showed high accumulation of the imaging agent at the tumor site. 111In radiometallation of the bioconjugate was performed in high radiochemical yield, highlighting the potential of this new BODIPY‐chelators derivative as a bimodal imaging probe. |
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| Keywords: | bimodal probes BODIPY DOTA MOMIP optical imaging |
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