Solvent-free 1,6-conjugate arylation of para-quinone methides: A greener approach to unsymmetrical triarylmethanes |
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| Affiliation: | 1. Department of Chemistry, Leshan Normal University, Leshan 614004, China;2. College of Chemistry and Pharmaceutical Engineering, ChongQing Industry Polytechnic College, Chongqing 401120, China;3. Key Laboratory of Applied Chemistry of Chongqing Municipality, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China |
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| Abstract: | A highly efficient arylation of para-quinone methides (p-QMs) with N,N-dimethylaniline under solvent free condition has been developed, which proceeded via a para-toluenesulfonic acid (TsOH)-promoted 1,6-conjugated addition pathway. This methodology provided a green and sustainable methodology to construct various novel unsymmetrical triarylmethanes (TAMs) with the advantages of good functional group tolerance, scalability, and regioselectivity. |
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| Keywords: | 1,6-Conjugated addition Green chemistry Neat condition TsOH-promoted Sustainable methodology |
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