Microwave-assisted synthesis of pyrazolo[3,4-d]pyrimidines from 2-amino-4,6-dichloropyrimidine-5-carbaldehyde under solvent-free conditions |
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| Authors: | Jairo Quiroga Jorge Trilleras Rodrigo Abonía Antonio Marchal |
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| Institution: | a Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A. A. 25360 Cali, Colombia
b Department of Inorganic and Organic Chemistry, Universidad de Jaén, 23071 Jaén, Spain |
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| Abstract: | The microwave-induced synthesis of pyrazolo3,4-d]pyrimidines 4 in the reaction of N4-substituted-2,4-diamino-6-chloro-5-carbaldehydes 3 with hydrazine is described here. Precursors 3 have been prepared by the mono-amination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde 2 with aliphatic and aromatic amines. The reaction times with primary amines were relatively shorter than for secondary amines. |
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| Keywords: | Formylation Vilsmeier-Haack reaction |
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