Co(III)/Zn(II)-catalyzed dearomatization of indoles and coupling with carbenes from ene-yne ketones via intramolecular cyclopropanation |
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Authors: | Na Li Junbiao Chang Lingheng Kong Shuangjing Wang Dandan Wang Miao Cheng Xingwei Li |
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Institution: | 1. Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, Henan, China;2. School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan, China;3. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China |
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Abstract: | A straightforward and efficient protocol for dearomatizing indoles is described. The reaction, catalyzed by an inexpensive Co(III)/Zn(II) catalyst, starts from easily accessible N-pyrimidinyl indoles and ene-yne ketones. Mild reaction conditions, high diastereoselectivity, a broad substrate scope, effective functional group tolerance, and reasonable to remarkable yields were observed. |
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Keywords: | Co(III)/Zn(II) catalysis Dearomatization Cyclopropanation Carbene Indole |
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