Hyperosmotic stimulus induces reversible angiogenesis within the hypothalamic magnocellular nuclei of the adult rat: a potential role for neuronal vascular endothelial growth factor |
| |
Authors: | Email author" target="_blank">Gérard?AlonsoEmail author Evelyne?Galibert Anne?Duvoid-Guillou Anne?Vincent |
| |
Institution: | 1.Departement d'Endocrinologie,CNRS UMR 5203; INSERM U661; Univ. Montpellier I and II; Institut de Génomique Fonctionnelle,Montpellier,France |
| |
Abstract: | Background In mammals, the CNS vasculature is established during the postnatal period via active angiogenesis, providing different brain
regions with capillary networks of various densities that locally supply adapted metabolic support to neurons. Thereafter
this vasculature remains essentially quiescent excepted for specific pathologies. In the adult rat hypothalamus, a particularly
dense network of capillary vessels is associated with the supraoptic (SON) and paraventricular (PVN) nuclei containing the
magnocellular neurons secreting vasopressin and oxytocin, two neurohormones involved in the control of the body fluid homoeostasis.
In the seventies, it was reported that proliferation of astrocytes and endothelial cells occurs within these hypothalamic
nuclei when strong metabolic activation of the vasopressinergic and oxytocinergic neurons was induced by prolonged hyperosmotic
stimulation. The aim of the present study was to determine whether such proliferative response to osmotic stimulus is related
to local angiogenesis and to elucidate the cellular and molecular mechanisms involved. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|