Synthesis of novel substituted 3,8,11-triazaspiro[5,6]dodecan-7-ones |
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Authors: | Lan-Ying Qin Andrew G ColeAxel Metzger Kurt W SaionzIan Henderson |
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Institution: | Ligand Pharmaceuticals Inc., 3000 Eastpark Blvd., Cranbury, NJ 08512, USA† |
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Abstract: | A synthesis of novel substituted 3,8,11-triazaspiro5,6]dodecan-7-ones using a combination of solution-phase and solid-phase chemistries is described. A solution-phase approach was used to produce a key piperidine intermediate that was then incorporated into a solid-phase synthesis. The combined synthetic strategy was applied to provide a series of substituted 3,8,11-triazaspiro5,6]dodecan-7-ones in good yield and high purity. |
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Keywords: | Triazaspiro[5 6]dodecan-7-one Solid phase |
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