Synthesis of spirocycles via ring closing metathesis of heterocycles carrying gem-diallyl substituents obtained via ring opening of (halomethyl)cyclopropanes with allyltributyltin |
| |
Authors: | Gurjar Mukund K Ravindranadh Somu V Sankar Kuppusamy Karmakar Sukhen Cherian Joseph Chorghade Mukund S |
| |
Institution: | National Chemical Laboratory, Pune, 411 008, India. |
| |
Abstract: | In the presence of allyl tri-n-butyltin--AIBN, cyclopropylmethyl bromides/xanthates undergo ring-opening reaction with concomitant formation of geminal diallyl derivatives in good yields. The ring closing metathesis reactions on geminal diallyl derivatives with Grubbs' catalyst provided spirocyclopentenyl products. Combination of these two methodologies has been applied to the synthesis of mono-, bis-cyclopentyl-carbohydrates as well as spirocyclopentylproline derivatives. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|