Synthesis of some new hetarylpyranopyridazines,cinnolines, and hetarylpyridazine derivatives |
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Authors: | M Abdel-Megid Y Gabr M A A Awas N M Abdel-Fatah |
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Institution: | (1) Bionomics Pty. Ltd., 31 Dalgleish St., Thebarton, SA, 5031, Australia;(2) Present address: Walter & Eliza Hall Institute, 4 Research Ave., Bundoora, VIC, 3086, Australia;(3) Present address: Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, VIC, 3052, Australia; |
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Abstract: | 4-Acetyl-5,6-diphenylpyridazin-3(2H)-one was condensed with 6-chloro-3-formylchromone under different reaction conditions
to yield the enone or pyranopyridazine. Both compounds were used in the synthesis of some new hetarylpyranopyridazines. Pyranodipyridazine
was obtained via a sequence of reactions of 4-acetyl-5,6-diphenylpyridazin-3(2H)-one with diethyl carbonate, acetic anhydride,
and 4-bromobenzenediazonium chloride. The reactions of pyridazinylbutane-1,3-dione with conc. H2SO4, POCl3, hydrazines, hydroxylamine
hydrochloride, cyanoacetamide, thiourea, and thiosemicarbazone were also studied. |
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