One-step conjugation of glycylglycine with [<Superscript>18</Superscript>F]FDG and a pilot PET imaging study期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study

Authors:	A. M. Şenışık Ç. İçhedef A. Y. Kılçar E. Uçar K. Arı D. Göksoy Y. Parlak Bedriye Elvan Sayıt Bilgin S. Teksöz

Affiliation:	1.Vocational School of Health Services/Radiotheraphy,Istanbul Kemerburgaz University,Ba?c?lar,Turkey;2.Department of Nuclear Applications, Institute of Nuclear Sciences,Ege University,Bornova,Turkey;3.Departmant of Nuclear Medicine,Celal Bayar University,Manisa,Turkey

Abstract:	This study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [¹⁸F]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 °C for 30 min in a vial containing AO-GlyGly and [¹⁸F]FDG solution. The radiolabeled product ([¹⁸F]FDG-GlyGly) was obtained with 98.65?±?0.35% yield without any purification step which makes this method more attractive for ¹⁸F radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [¹⁸F]FDG tagged GlyGly in vivo.

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