Efficient One-Step Passivation of Polyurethane Using Transurethanization |
| |
Authors: | Benoît Rhoné Anouk Galtayries Vincent Semetey |
| |
Institution: | Chimie ParisTech, PSL University, CNRS, Institut de Recherche de Chimie Paris, 11 Rue Pierre et Marie Curie, Paris, 75005 France |
| |
Abstract: | The uncontrolled accumulation of biological materials on the surface of medical devices through protein adsorption or cell adhesion causes adverse biological reactions in the living host system, leading to complications. In this study, poly(ethylene glycol) (PEG) is successfully grafted onto polyurethane (PU) surfaces by using a new strategy through a simple and efficient transurethanization reaction. The PEG hydroxyl group is deprotonated and then reacted with the PU surface to provide antiadhesive hydrophilic surfaces in a single step. Surface analysis techniques proved the grafting to be efficient and the formation of a hydrophilic polymeric layer at the surface of PU. Biological assays showed that the surface modification induced lower protein adsorption, cell, platelet, and bacterial adhesion than untreated surfaces, showing a potential for biomedical applications. |
| |
Keywords: | antifouling grafting polyurethane surface transurethanization |
|
|