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Application of chiral dipyridylmethane ligands in the enantioselective palladium-catalyzed allylic alkylation |
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| Authors: | Giorgio Chelucci, Simona Chessa,Gianmauro Orr |
| Affiliation: | Dipartimento di Chimica, Università di Sassari, via Vienna 2, I-07100, Sassari, Italy |
| Abstract: | New chiral C1-symmetric dipyridylmethane ligands have been prepared from naturally occurring monoterpenes according to a method based on two consecutive constructions of the pyridine rings. These ligands have been assessed in the enantioselective palladium catalyzed allylic alkylation of 1,3-diphenylprop-2-enyl acetate with dimethylmalonate. Enantioselectivity up to 68% ee has been obtained. |
| Keywords: | Chiral dipyridylmethane Nitrogen heterocycles Palladium complex Allylic alkylation Enantioselectivity |
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