Separation and Determination of Nitroguanidine and Guanidine Nitrate by HPTLC |
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Authors: | M Chaloosi M Amoli-Diva F Gholamian S Mozaffari |
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Institution: | (1) Faculty of Chemistry, Tarbiat Moalem University, 49 Mofateh Avenue, Tehran, Iran;(2) Faculty of Chemistry, Malek Ashtar University, Tehran, Iran |
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Abstract: | High-performance thin-layer chromatography has been used for separation and quantification of nitroguanidine and guanidine
nitrate, for online and off-line quality control of synthesis. The compounds were separated on silica gel 60 F254 layers with dioxane–tetrahydrofuran 1:1 (v/v), as mobile phase. UV detection was performed at 210 and 265 nm for guanidine nitrate and nitroguanidine, respectively. Quantitative
analysis was performed by absorbance densitometry and use of peak area. Validation was performed taking into consideration
the special features of the method. |
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Keywords: | Thin-layer chromatography Nitroguanidine Guanidine nitrate |
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