Unusual and unexpected reactivity of t-butyl dicarbonate (Boc2O) with alcohols in the presence of magnesium perchlorate. A new and general route to t-butyl ethers |
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| Authors: | Bartoli Giuseppe Bosco Marcella Locatelli Manuela Marcantoni Enrico Melchiorre Paolo Sambri Letizia |
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| Institution: | Dipartimento di Chimica Organica "A. Mangini", v.le Risorgimento 4, I-40136 Bologna, Italy. giuseppe.bartoli@unibo.it |
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| Abstract: | reaction: see text] A new mild method for protecting alcohols as t-butyl ethers is reported. The reaction proceeds with Mg(ClO4)2 and Boc2O and shows general applicability. The deprotection of t-butyl ethers has also been revisited. Preliminary results indicate the CeCl3 x 7H2O/NaI system is a very suitable catalyst for their removal. |
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