Prediction, Synthesis and Antigenicity of the Antigenic Peptides of 26kDa Glutathione S-Transferasc of Schistosoma Japonicum (Sj26) |
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| Authors: | Jia Xi XU Meng Shen CAI |
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| Institution: | a College of Chemistry and Molecular Engineering, Peking University, Beijing 100871;b School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083 |
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| Abstract: | Six antigenic peptides of 26 kDa glutathione S-transferase of Schistosoma japonicum (Sj26) have been predicted according to their hydrophilicity. flexibility, accessibility, charge distribution and β -turn in the secondary structure by the determination of its primary structure and synthesized by solid phase method. All of them showed antigenicity with anti-schistosoma japonicum immunoglobulin polyclonal antibody, anti-Sj-IgG PcAb by Dot-ELISA. Three of them showed good antigenicity. They would serve as candidates of synthetic anti-schistosomal vaccine. |
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| Keywords: | SchistosomajQPonicum glutathione S-transferase antigenic peptide peptide vaccine |
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