| 糖芯片研究 |
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| 引用本文： | 薛彦峰,王秀奎,侯信,姚康德.糖芯片研究[J].化学进展,2008,20(1):148-154. |
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| 作者姓名： | 薛彦峰 王秀奎 侯信 姚康德 |
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| 作者单位： | 1. 天津大学化工学院,天津,300072
2. 天津大学材料科学与工程学院,天津,300072 |
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| 摘 要： | 糖芯片是继基因芯片、蛋白质芯片、组织芯片等之后发展起来的一种很有前景的生物检测技术,具有检测样品用量少、特异性高、高通量等优点,可以大大提高糖化学研究的效率。本文介绍利用共价结合法和非共价吸附法制备二维糖芯片,利用聚合反应制备三维凝胶芯片以及糖芯片在凝集素功能研究、病毒转染机制研究、细菌检测和免疫学研究等方面的应用,最后对糖芯片今后的发展进行了展望。
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| 关 键 词： | 薛彦峰" target="_blank">face="Verdana">薛彦峰 王秀奎 侯信 姚康德 |
| 文章编号： | 1005-281X（2008）01-0148-07 |
| 收稿时间： | 2007-02 |
| 修稿时间： | 2007-04 |
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| Xue Yanfeng,Wang Xiukui,Hou Xin,Yao Kangde.null[J].Progress in Chemistry,2008,20(1):148-154. |
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| Authors: | Xue Yanfeng Wang Xiukui Hou Xin Yao Kangde |
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| Institution: | (1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072,China|2. School of Materials Science and Engieering, Tianjin University, Tianjin 300072|China) |
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| Abstract: | Carbohydrate microarray is a new kind of promising biological detection technology following the gene microarray, protein-chip and tissue microarray. The efficiency and speed of carbohydrate chemistry research are improved due to the advantages of carbohydrate microarray such as less dosage of samples, higher specificity and high-throughput. This article introduces the preparations of 2D carbohydrate microarray based on covalent immobilization and noncovalent physical adsorption. A novel method of designing 3D gel carbohydrate microarray based on polymerization is also described. The applications of carbohydrate microarray in lectins function research, virus infection, bacteria detection and immunological research are introduced likewise. Finally, the future trend of carbohydrate microarray is also discussed. |
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| Keywords: | carbohydrate microarray biomicroarray lectins function virus infection bacteria detection |
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