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Effects of Pre-exposure Mouse Pituitary with Low-dose ^60Co γ-ray on Growth Hormone (GH) and Body Mass Induced by Subsequent High-dose Irradiation
作者姓名:ZhangHong  LiWenjian  JingXiaodong  LiuBing  MinFengling  ZhouQingming  XieYi
摘    要:The pituitary of the B6C3F1 hybrid strain mice were irradiated with 0.05 Gy of ^60Co γ-ray as the pre-exposure dose (D1), and were then irradiated with 2 Gy of ^60Co γ-ray as challenging irradiation dose (D2) at 4h after per-exposure. Body weight and serum growth hormone (GH) were measured at 35th day after irradiation. The results showed that irradiation of mouse testes with 2 Gy of ^60Co γ-ray significantly diminished mousebody weight and level of serum GH (Table). Pre-exposure with a low-dose (0.05 Gy) of ^60Co γ-ray significantly alleviated reductions of mouse body weight and level of serum GH induced by subsequent a high-dose (2 Gy) irradiation (Table). The data suggested that low-dose ionizing irradiation can induce adaptive responses to the harmful effects of pituitary by subsequent high-dose exposure.

关 键 词:低剂量钴  放射性  鼠生物实验  伤害效应
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