| 牛黄酸及水杨酸系药物对镁铝层状复合氢氧化物的插层组装 |
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| 引用本文： | 苟国敬,许红平,鲍凤娟,刘建平.牛黄酸及水杨酸系药物对镁铝层状复合氢氧化物的插层组装[J].化学研究与应用,2009,21(1). |
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| 作者姓名： | 苟国敬 许红平 鲍凤娟 刘建平 |
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| 作者单位： | 宁夏医学院基础学院,宁夏,银川,750004 |
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| 基金项目： | 教育部科学技术研究重点项目，宁夏自然科学基金，宁夏高等学校科学技术研究基金，宁夏医学院特殊人才科研启动项目 |
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| 摘 要： | 通过XRD和IR表征对镁铝层状复合氧氧化物(LDH)与水杨酸、乙酰氨基酚、乙酰水杨酸,以及谷氨酸、色氨酸、牛黄酸反应产物的比较分析,研究了不同药物对有关组装方式的适宜性.结果表明水杨酸类药物均可通过离子交换组装到LDH层间,晶胞参数c由2.3893 nm依次增大为2.4024、2.4110和2.4111nm,通道高度h由0.3194 nm增大为0.3238、0.3267和0.3268 nm;通过离子交换能将谷氨酸组装到LDH层间,产物的IR吸收、热分解行为及TEM形貌与前体有明显区别,晶胞参数c由2.3765nm增大为2.3851nm,h由0.3152nm增大为0.3180nm;共沉淀法适宜制备LDH-牛黄酸插层复合物,但简单的离子交换不能使色氨酸与LDH有效复合.
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| 关 键 词： | 层状复合氢氧化物 水杨酸系约物 牛黄酸 捕层组装 |
Intercalation of MgAl layered double hydroxide with taurine and salicylic acid type drugs |
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| GOU Guo-Jing,XU Hong-ping,BAO Feng-juan,LIU Jian-ping.Intercalation of MgAl layered double hydroxide with taurine and salicylic acid type drugs[J].Chemical Research and Application,2009,21(1). |
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| Authors: | GOU Guo-Jing XU Hong-ping BAO Feng-juan LIU Jian-ping |
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| Institution: | Ningxia Medical college School of Basic Medical Science;Yinchuan 750004;China |
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| Abstract: | Intercalation compounds of layered double hydroxide(LDH)with salicylic acid,paracetamol and acetosalicylic acid have been synthesized via ion exchange reaction,and the expected intercalation of LDH with glutamic acid,tryptophan and taurine are also prepared via co-precipitation and ion exchange reactions,the intercalation effects of different drugs are investigated through XRD and FT-IR characterizations.The result show that the salicylic acid type drugs could be successfully intercalated into the interlaye... |
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| Keywords: | LDH salicylic acid type drugs taurine intercalation |
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