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Enantioselective reductive aldol reaction using tertiary amine as hydride donor |
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| Authors: | Kazuki OsakamaMasaharu Sugiura Makoto Nakajima Shunsuke Kotani |
| Affiliation: | a Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan b Priority Organization for Innovation and Excellence, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan |
| Abstract: | An efficient method was developed for the enantioselective reductive aldol reaction of α,β-unsaturated ketones with aldehydes in the presence of a Lewis base catalyst; conjugate reduction using a tertiary amine and trichlorosilyl triflate, followed by an aldol reaction with BINAP dioxide (BINAPO) as an organocatalyst, gave the corresponding product in high yield with high stereoselectivity. |
| Keywords: | Aldol reaction Asymmetric catalysis Conjugate reduction Phosphine oxide Tertiary amine |
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