Design and preparation of pH-responsive curdlan hydrogels as a novel protein delivery vector |
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| Authors: | Ze-chuan Yang Yan-chun Li Fan Li Qing-rong Huang Guo Zhang Tong-fei Shi |
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| Institution: | 1. Institute of Materials Science and Engineering,Jilin University,Changchun 130012,China;State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;2. Department of Pediatric Respiratory Medicine,First Hospital of Jilin University,Changchun 130021,China;3. State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;4. Food Science Department,Cook College Rutgers University,New Brunswick,NJ 08901-8520,United States;5. Institute of Materials Science and Engineering,Jilin University,Changchun 130012,China |
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| Abstract: | New pH-responsive saccharide hydrogels were designed and prepared using curdlan derivatives(curdlan-Bochistidine, CUR-HIS). The CUR-HIS hydrogels possessed highly porous structures. The swelling ratios of CUR-HIS hydrogels increased with the degree of substitution of Boc-histidine groups. And the addition of 0.5 mol/L Na Cl provoked a sharp reduction of swelling ratio of CUR-HIS hydrogels. Bovine serum albumin(BSA) can be efficiently encapsulated into CUR-HIS hydrogels. Moreover, the release profiles of BSA at different p H values from CUR-HIS hydrogels were significantly different. These hydrogels showed good biocompatibility in the cytotoxicity assays. The CUR-HIS hydrogels are of great potential in biomedical applications such as protein delivery systems. |
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| Keywords: | pH-responsive Hydrogel Protein Delivery |
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