Hydrolytic Pathway of Glufosfamide,a New Phosphorylated Anticancer Agent |
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| Authors: | Marie-Caroline Aoust de Rouvèze Veronique Gilard Robert Martino Myriam Malet-Martino Ulf Niemeyer |
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| Affiliation: | 1. Biomedical NMR Group, IMRCP Laboratory , Université Paul Sabatier , 118, route de Narbonne, Toulouse , 31062 , France;2. ASTA Medica AG , Franckfurt am Main , Germany |
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| Abstract: | 31 P NMR was used to demonstrate that glufosfamide is hydrolyzed into isophosphoramide mustard (IPM) with a half-life of about 25 h at 37;C and pH 7.4 in buffer as well as in human plasma. Through a cascade of reactions, IPM gives rise to three final products, dihydroxyIPM, phosphate ion, and phosphorylethanolamine, which is by far the major compound. |
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| Keywords: | Glufosfamide Hydrolysis Isophosphoramide Mustard |
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