The Microwave-Assisted Dehydrative Cyclization of Thiosemicarbazides Forming Substituted 1,2,4-Triazoles |
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Authors: | Khosrow Zamani Shirindokht Bagheri |
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Institution: | Department of Chemistry , Arak University , Arak, Iran |
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Abstract: | Different types of 4,5-disubstituted 1,2,4-triazole-3-thiones were prepared by microwave irradiation as well as by a classical method. The beneficial effect of microwave irradiation on the dehydrative cyclization of thiosemicarbazides in different reaction media is described. Our results show that the effect of microwave irradiation on the reaction studied was the shortening of reaction times (from 2–9 h to 2–4 min) and a minor decrease (1–4%) in yields. The structure of the new compounds was established by FTIR, MS, and 1H NMR spectral data. |
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Keywords: | Cyclization microwave thiosemicarbazides |
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