Ring-Closing Metathesis Strategies to P -heterocycles |
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Authors: | Kevin T Sprott Matthew D McReynolds Paul R Hanson |
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Institution: | Department of Chemistry , University of Kansas , Lawrence , KS |
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Abstract: | A general approach to the synthesis of P -heterocycles using the ring-closing metathesis reaction is described. We have developed a new method utilizing phosphorus nuclei as suitable temporary tethers for the coupling of non-racemic allylic amines. This approach allows for the generation of symmetric and unsymmetric 1,4-diamines. Subsequent coupling of these 1,4-diamines with various nuclei produces an array of 7-membered heterocycles. |
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Keywords: | 1 4-Diamine P -heterocycle Ring-closing Metathesis Cyclic Phosphonamide Temporary Phosphorus Tether |
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