Heterogeneous Thiocyanation of Benzylic Alcohols and Silyl and THP Ethers,and Deprotection of Silyl and THP-Ethers by [PCl3-n(SiO2)n] (Silphos) |
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| Authors: | N Iranpoor H Firouzabadi H Bahador A Jamalian |
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| Institution: | 1. Chemistry Department , College of Sciences, Shiraz University , Shiraz, Iran;2. Medicinal &3. Natural Products Chemistry Research Centre , Shiraz University of Medical Sciences , Shiraz, Iran |
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| Abstract: | Silicaphosphite (silphos), PCl3-n(SiO2)n], as a heterogeneous phosphorous compound, catalyzes the thiocyanation of benzylic alcohols and silyl and THP ethers in the presence of I2 and NH4SCN in refluxing CH3CN. The produced silphos oxide byproduct can be easily separated by a simple filtration. Silphos is also used for the efficient and selective deprotection of silyl and THP-ethers to their corresponding alcohols. |
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| Keywords: | Alcohol deprotection silyl ether silphos thiocyanation THP-ether |
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