Studies on Thiazolopyridines. Part 3: Reactivity of Thiazolo[3,2- a ]-3-aza[1,8]naphthyridine Towards Some Nucleophiles |
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Authors: | Gameel A M El-Hag Ali |
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Institution: | Al-Azhar University , Cairo, Egypt |
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Abstract: | A variety of new thiazolo3,2- a ]pyridine derivatives 2a-h having 3-indolyl group were produced by refluxing 1a with different benzylidenemalononitrile derivatives. Reactivity of compound 4 toward some nitrogen nuclcophiles was investigated. Thus, the novel pyrazoles 6a , b were obtained when compound 4 was allowed to react with hydrazine and phenyl hydrazine in ethanol under reflux. On the other hand, pyrazolo3',4':4,5]thiazolo3,2- a ]-3-aza1,8]naphthyridine 8 was formed by condensation of compound 4 with benzoyl hydrazine. Finally, condensed heterocyclic compounds containing pyran rings 9 and 10 were obtained by treatment compound 4 with active ethylene compounds. |
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Keywords: | Thiazolo[3 2- a ]-3-aza[1 8]naphthyridine Thiazolo[3 2- a ]pyridine |
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