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Thio Analogues of Pyrimidine Bases: Syntheses and Spectral Study of New Potentially Biologically Active 2,4-Di-Ortho-(Meta- and Para-)Bromo- (Chloro and Nitro)-Benzylthio-5-Bromouracils (and 6-Methyluracils) |
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| Authors: | Grażyna Bartkowiak Elżbieta Wyrzykiewicz Grzegorz Schroeder Anna Walkowiak Anna Szponar Ilona Pawlak |
| Institution: | Faculty of Chemistry , Adam Mickiewicz University , Poznań, Poland |
| Abstract: | Eighteen new 2,4-di-ortho- (meta- and para-) bromo-(chloro- and nitro-)benzylthio-5-bromouracils (and 6-methyluracils) have been prepared. The structures of these compounds were confirmed by spectral (IR, UV/vis, 1H NMR) and elemental analyses. Estimation of pharmacotherapeutic potential has been made for synthesized compounds on the basis of prediction of activity spectra for substances (PASS). |
| Keywords: | 2 4-Dibenzylthio-5-bromo-6-methyluracils 2 4-dibenzylthio-5-bromouracils 1H NMR IR PASS structural isomers UV/vis |