Studies on Azolylacetonitriles: The Reactivity of Thiazole-2-yl,Thiadiazol-2-yl Acetonitriles Toward Electrophilic Reagents |
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| Authors: | M H Elnagdi M A Selim F M Abd El Latif S Samia |
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| Institution: | 1. Chemistry Department, Faculty of Science , Cairo University , Egypt;2. Chemistry Department, Faculty of Science , South Valley University , Aswan , Egypt |
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| Abstract: | 5-Acetyl-2-cyanomethyl-4-methylthiazole, 2-aminothiazole, and 5-N-benzoylamino-1,3,4-thiadiazole-2-yl-acetonitrile react with acetone, and malononitrile derivatives in the presence of sulfur to yield the corresponding thiophene derivatives. Also, 4-furylmethylene-2-phenyl-2-oxazolin-5-ones react with thiophenol, and/or thionaphthol to give the thiolester derivatives in one-pot synthesis. The structures of the products were based on IR, 1 H NMR, and elemental analysis. |
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| Keywords: | 2-Aminothiophenes Spectra Synthesis Thiadiazole Thiazole Thiolester |
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