A Facile Synthesis of Novel 9-Methyl[1, 2, 3]Selenadiazoles[4, 5-b]Quinoline and 9-Methyl[1, 2, 3]Thiadiazole[4, 5-b]Quinoline as a New Class of Antimicrobial Agents |
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Authors: | Halehatty S Bhojya Naik Machenahalli S Ramesha Boovanahalli V Swetha Thopenahalli R Roopa |
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Institution: | Department of Studies and Research in Industrial Chemistry , Kuvempu University , Shankarghatta, Shimoga, India |
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Abstract: | 2-chloro-4-methyl quinoline 2 on condensation with semicarbazide hydrochloride gave its semicarbazone. This on reaction with SeO 2 and SOCl2 yielded a new class of novel selenadiazoles 4 and thiadiazoles 5, respectively. The structure of all the compounds were elucidated on the basis of elemental analysis, IR, 1 H NMR, and the mass spectral data. Some derivatives of 9-methyl1, 2, 3]selenadiazole4, 5-b] quinoline and 9-methyl1, 2, 3]thiadiazole 4, 5-b]quinoline have been screened for antimicrobial activities. |
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Keywords: | 2-Chloro-4-methyl quinoline microbial activities semicarbazones selenadiazoles thiadiazoles |
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