Stereoselective Synthesis of Phosphorus Analogs of (R)-Carnitine and (R)-Gabob |
| |
| Authors: | Cheng-ye Yuan Ke Wang Jinfeng Li Zu-yi Li |
| |
| Affiliation: | Shanghai Institute of Organic Chemistry , Chinese Academy of Science , Shanghai, China |
| |
| Abstract: | Bioreduction of 3-substituted-2-oxoalkanephosphonates by baker's yeast afforded corresponding 2-hydroxy-alkanephosphonates in good yields and ee value. These compounds ( 2a,b ) could serve as useful chirons for the stereoselective synthesis of phosphorus analogs of (R)-Carnitine and (R)-GABOB. |
| |
| Keywords: | Baker's Yeast Bioreduction Hydroxyphosphonates |
|
