Synthesis of Some New Biologically Active Sulfur Compounds Containing Pyrazolo[3,4-d] pyrimidine Moiety |
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| Authors: | Zeinab H. Ismail Soad M. Abdel-Gawad Anhar Abdel-Aziem M. M. Ghorab |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science , Al-Azhar University (Girls) , Cairo, Egypt;2. Department of Chemistry, Faculty of Science , Al-Azhar University (Girls) , Cairo, Egypt;3. National Center for Radiation Research and Technology , Cairo, Egypt |
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| Abstract: | ![]()
A novel series of the pyrazolo[3,4-d]pyrimidines having biologically active sulfur moieties 3-20 were prepared via reaction of 4-mercapto-1-phenyl-1 H -pyrazolo[3,4-d]pyrimidine 3 with different reagents. Identification of the new compounds was established by elemental analyses, IR, 1 H-NMR, and mass spectral data. Some of the obtained compounds showed the interesting antimicrobial activity comparable to antibiotic chloramphenicol as standard antibacterial agent and Terbinafin as a standard antifungal agent. |
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| Keywords: | Sulfur Containing Pyrazolo[3 4-d]pyrimidine And Antimicrobial Activity |
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