The One Step Synthesis of 2-(2-Bromo-5- methoxyphenyl)-5-(3-arylidene)-1,3-thiazolo[3,2-b]- 1,2,4-triazol-6-(5H)-ones and the Evaluation of the Anticonvulsant Activity |
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| Authors: | K K Vijaya Raj B Narayana |
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| Institution: | Department of Postgraduate Studies and Research in Chemistry , Mangalore University , Mangalagangotri , India |
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| Abstract: | A smooth one-step synthesis of 2-(2-bromo-5-methoxyphenyl)-5-(3-arylidene)-1,3-thiazolo3,2-b]-1,2,4-triazol-6-(5H)-ones (4a–n) is described. The newly prepared compounds are characterized by analytical and IR, 1 H NMR, 13 C NMR, and FABMS spectral analysis. A few compounds are screened for anticonvulsant activity. Compounds 4i and 4n exhibit promising anticonvulsant activity and are recommended for further studies. |
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| Keywords: | Anticonvulsant activity bromomethoxyphenyl one step synthesis thiazolotriazolones |
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