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The Rational Design of Drugs with Phos-phonic/phinic Acids as Enzyme Inhibitors Isosteric Receptor Ligands |
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| Authors: | Frank H. Ebetino David L. Soper Michelle J. Dirr Mark W. Lundy Glen Mieling John A. Wos |
| Affiliation: | 1. Health Care Research Center , Procter &2. Gamble Pharmaceuticals , Mason , Ohio |
| Abstract: | Phosphonic/phosphinic acid analogs have been studied for inhibitory and ligand activity in farnesyl pyrophosphate synthase, prostaglandin, and other GPCR's. |
| Keywords: | Isosteres Peptidomimetic Phosphinic/phosphonic Acids Prostaglandins |