| A convenient synthesis of 2β,3α-dihydroxyurs-12-en-28-oic acid as a natural diastereoisomer of corosolic acid |
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| 作者姓名： | Shi-Sheng Wang Li-Juan Luo Zhi-Gang Gao Tong-Wei Guan Wei-Jie Zhao |
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| 作者单位： | School of Pharmaceutical Science and Technology,Dalian University of Technology |
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| 基金项目： | Financial support from the Fundamental Research Funds for the Central Universities(No.DUT12JB08) |
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| 摘 要： | 2β,3α-Dihydroxyurs-12-en-28-oic acid（6） is a naturally occurring diastereoisomer of corosolic acid with glycogen phosphorylase inhibitory activity.A new strategy for the semi-synthesis of 6 was developed.Using the commercially available ursolic acid（1） as the starting materials,6 was synthesized through five facile reactions with a high stereoselectivity and an overall yield of 47.3%.The structure of 6 was confirmed by optical rotation.ESI-MS,1H NMR and 13C NMR data.
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| 关 键 词： | 2β,3α-Dihydroxyurs-12-en-28-oic acid Ursolic acid Glycogen phosphorylase Corosolic acid |
| 收稿时间： | 2013-01-10 |
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