Bioactive isocoumarins from a terrestrial Streptomyces sp. ANK302 |
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| Authors: | Zinad Dhafer Saber Shaaban Khaled A Abdalla Muna Ali Islam Md Tofazzal Schüffler Anja Laatsch Hartmut |
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| Institution: | Institute of Organic and Biomolecular Chemistry, University of G?ttingen, Tammannstrasse 2, D-37077 G?ttingen, Germany. |
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| Abstract: | Four isocoumarins have been isolated from the terrestrial Streptomyces sp. ANK302, namely 6,8-dimethoxy-3-methylisocoumarin (1), 6,8-dihydroxy-3-methylisocoumarin (2), 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (3), and 6,7,8-trimethoxy-3-methylisocoumarin (4). Compound 1 is a new naturally-occurring isocoumarin, and 2 was isolated as a new bacterial product. The structures 1-4 were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. Compound 2 showed a strong zoosporicidal activity at a concentration of 5 microg/mL against a phytopathogenic oomycete, Plasmopara viticola, and 1 was active against |
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